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While SLC7A11 generally plays a protective role under stress conditions, whether and how the NADPH dependency imposed by SLC7A11-mediated cystine uptake can affect cellular adaptation to these other stress conditions remain to be further studied

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ROS was thought to be the by-product of normal metabolism 27 but was elevated largely when faced with oxidative stress, including hydrogen peroxide (H2O2), hydroxyl radical (·OH), superoxide radical (·O2-), and oxygen (O2)